Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 10
Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention
In mutant SOD1 transgenic mouse models, a high‑caloric, high‑fat diet or ketogenic diet generally had protective effects on ALS; however, in the mouse models, the pathogenesis is mainly associated with oxidative stress. The effect of energy intake and diets on other ALS mechanisms should be further investigated. On the other hand, studies have provided certain evidences to support hypercaloric nutrition as a potential intervention for ALS patients, but large sample‑size, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 9
Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis
Background: Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal cord.
Objective: We analyzed the spinal cords of G93A mice following dietary D3 restriction at 2.5% the adequate intake (AI) for oxidative damage ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 8
Dietary intake and zinc status in amyotrophic lateral sclerosis patients
Ingesta dietética y estado de zinc en pacientes con esclerosis lateral amiotrófica
Introducción: hay pruebas considerables de que los cambios en la homeostasis del zinc están relacionados con la patogénesis de la esclerosis lateral amiotrófica (ELA) y que la malnutrición es un factor pronóstico capaz de reducir la supervivencia de los pacientes con ELA.
Objetivo: evaluar la ingesta dietética y el estado de zinc en pacientes con ELA, tratados en un centro de atención ambulatoria especializado en ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 7
Complementary and Alternative Therapies in ALS
Given the severity of their illness and lack of effective disease modifying agents, it is not
surprising that most patients with ALS consider trying complementary and alternative therapies. Some of the most commonly considered alternative therapies include special diets, nutritional supplements, cannabis, acupuncture, chelation and energy healing. This chapter reviews these in detail. We also describe 3 models by which physicians may frame discussions about alternative therapies: paternalism, autonomy and shared decision making. ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 6
Blood Levels of Trace Metals and Amyotrophic Lateral Sclerosis
Some trace metals may increase risk of amyotrophic lateral sclerosis (ALS), whereas others may
be beneficial. Our goal was to examine associations of ALS with blood levels of selenium (Se),
zinc (Zn), copper (Cu), and manganese (Mn). We conducted a case-control study of 163
neurologist confirmed patients from the National Registry of Veterans with ALS and 229
frequency-matched veteran controls. We measured metal levels in blood using inductively coupled plasma mass spectrometry and estimated odds ratios (ORs) and ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 5
Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival
Abstract Background: There are inconsistences regarding the correlation between diabetes or fasting blood glucose concentrations and the risk and survival of amyotrophic lateral sclerosis (ALS) in the previous studies. Moreover, the association between hemoglobin A1c (HbA1c) levels, which reflect long-term glycemic status, and ALS survival was not examined. Methods: A prospective cohort study including 450 Chinese sporadic ALS patients (254 men and 196 women; mean age: 55.4 y). We identified 223 deaths during average ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 4
Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis
IMPORTANCE—There is growing interest in the role of nutrition in the pathogenesis and
progression of amyotrophic lateral sclerosis (ALS).
OBJECTIVE—To evaluate the associations between nutrients, individually and in groups, and
ALS function and respiratory function at diagnosis.
DESIGN, SETTING, AND PARTICIPANTS—A cross-sectional baseline analysis of the
Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 3
Assessment and nutrition education in patients with amyotrophic lateral sclerosis
Avaliação e educação nutricional em pacientes com esclerose lateral amiotrófica
Pacientes neurológicos com esclerose lateral amiotrófica frequentemente evoluem com piora do estado nutricional. O objetivo desse estudo foi comparar o estado nutricional e a ingestão alimentar depois da orientação nutricional em pacientes com ELA. Variáveis clínicas, antropométricas e funcionais foram analisadas. 53 pacientes foram avaliados na fase inicial da doença. A pontuação média da escala de ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 2
Anti-inflammatory therapies of amyotrophic lateral sclerosis guided by immune pathways
Abstract: Sporadic ALS patients display heterogeneous immune pathways in peripheral blood mononuclear cells (PBMCs). We tested nine sALS patients and one unaffected identical twin of an index case by RNA-Seq of PBMCs. The inflammatory patients (n = 3) clustered into a subset with an inflammatory Th1/Th17 signature and the noninflammatory patients (n = 7) into another subset with a B cell signature. The inflammatory subset was remarkable for granulocyte and agranulocyte diapedesis, hepatic fibrosis, ...
Nutrição e ELA (Esclerose Lateral Amiotrófica) – Artigo 1
A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases. However, the variance among individual studies examining ALS oxidative stress clouds corresponding conclusions. Therefore, we construct a comprehensive, temporal view of oxidative stress and corresponding antioxidant ...